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- Title
Invited Perspective: Closing the Loop of Nonmonotonicity-from Natural Hormones in Experimental Endocrinology to Endocrine Disruptors in Epidemiology.
- Authors
Soto, Ana M.; Sonnenschein, Carlos
- Abstract
The article comments on a study which investigated a type of nonmonotonic dose-response curve (NMDRC), an inverted U-risk trend between total effective xenoestrogen (TEXB) levels in serum and endometrial cancer, and the health effects of exposure to endocrine disruptors. It suggests the potential therapeutic use of high doses of estrogen for breast cancer and calls for epidemiologists to stop expecting monotonic dose-response curves as the norm.
- Subjects
ENDOCRINOLOGY; ESTROGEN; ENDOMETRIAL tumors; DOSE-effect relationship in pharmacology; ESTRADIOL; ENVIRONMENTAL exposure; DISEASE risk factors
- Publication
Environmental Health Perspectives, 2024, Vol 132, Issue 2, p021304-1
- ISSN
0091-6765
- Publication type
Article
- DOI
10.1289/EHP14499