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- Title
Modulation of Lipopolysaccharide-Induced Chorioamnionitis in Fetal Sheep by Maternal Betamethasone.
- Authors
Wolfe, Katherine B.; Snyder, Candice C.; Gisslen, Tate; Kemp, Matthew W.; Newnham, John P.; Kramer, Boris W.; Jobe, Alan H.; Kallapur, Suhas
- Abstract
Objective: Wetestedthehypothesisthattheorderofexposuretomaternalbetamethasoneandintra-amniotic(IA)lipo- polysaccharide(LPS)willdifferentiallymodulateinflammationinthechorioamnion. StudyDesign: Time-matedMerinoewes withsingletonfetusesreceivedsalinealone,IALPSalone,maternalbetamethasonebeforeLPS,orbetamethasoneafterLPS. Weassessedinflammatorymarkersinthechorioamnionandtheamnioticfluid. Results: Inflammatorycellinfiltration, expressionofmyeloperoxidase,serumamyloidA3(acutephasereactant)inthechorioamnion,andlevelsofinterleukin(IL)-8in theamnioticfluidincreased7daysafterLPSexposure.BetamethasonepriortoLPSdecreasedinfiltrationoftheinflammatory cells,CD3+Tcells,anddecreasedthelevelsofIL-1ß andIL-8intheamnioticfluid.Conclusions:Betamethasone7dayspriorto LPSexposuresuppressedLPS-inducedinflammation.Themarkersofinflammationlargelyhadreturnedtothebaseline14days afterLPSexposure.
- Subjects
PHYSIOLOGICAL effects of lipopolysaccharides; PHYSIOLOGICAL effects of steroids; FETAL membrane abnormalities; SHEEP; PREGNANCY in mammals; MERINO sheep; REPRODUCTION
- Publication
Reproductive Sciences, 2013, Vol 20, Issue 12, p1447
- ISSN
1933-7191
- Publication type
Article
- DOI
10.1177/1933719113488445