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- Title
Hydroxychloroquine is effective in oral lichen planus: A multicenter, randomized, controlled trial.
- Authors
Xie, Yulang; Xu, Hao; Li, Chunlei; Wang, Yufeng; Lu, Rui; Hua, Hong; Tang, Guoyao; Zhou, Gang; Jin, Xin; Shang, Qianhui; Dan, Pan; Zhang, Chengli; Luo, Xiaobo; Dan, Hongxia; Zeng, Xin; Zhou, Yu; Chen, Qianming
- Abstract
Objectives: This study was aimed to evaluate the safety and benefit of short‐term application of hydroxychloroquine in the management of atrophic/erosive/ulcerative oral lichen planus (OLP). Methods: This multicenter, randomized, controlled, evaluator‐blinded, prospective clinical trial was performed from October 1, 2019, to September 1, 2022. A total of 99 patients were randomized to receive systemic use of hydroxychloroquine (n = 50), or topical use of 0.05% dexamethasone (n = 49) for 4 weeks. The response to both treatment modalities was evaluated according to reticulation, hyperemic, and ulceration (RHU) score and visual analog scale (VAS) score. Results: After 4 weeks of medication, both groups showed substantial reduction in RHU and VAS score (p < 0.05). In hydroxychloroquine group, the average of RHU score was reduced from 10.60 to 7.68 (dropped 27.49%), and the average of VAS score was reduced from 3.74 to 2.47 (dropped 34.09%). There were no differences between the two groups in reduction of RHU score and VAS score (p > 0.05). Single factor analysis found hyperemic area (p = 0.019) and erosive/ulcerative area (p = 0.024) had impacts on drug efficacy of hydroxychloroquine, and logistic regression revealed that no factors (p > 0.05) influenced its efficacy. Conclusion: These findings indicate hydroxychloroquine is a safe and effective agent in treating atrophic/erosive/ulcerative OLP.
- Subjects
HYDROXYCHLOROQUINE; PATIENT safety; RESEARCH funding; STATISTICAL sampling; VISUAL analog scale; LOGISTIC regression analysis; RANDOMIZED controlled trials; DESCRIPTIVE statistics; LONGITUDINAL method; DRUG efficacy; RESEARCH; ORAL lichen planus; FACTOR analysis; EVALUATION
- Publication
Oral Diseases, 2024, Vol 30, Issue 5, p3126
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.14746