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- Title
Relationship Between Fc Receptors and la Alloantigens: Analysis with a Sensitive Radioimmunoassay.
- Authors
Rieber, E. P.; Wernet, P.
- Abstract
This paper describes the successful use of 125I-labeled IgG aggregate to detect Ia-type alloantibodies in pregnancy sera. The blockade of aggregate uptake of a variety of normal mononuclear and leukemic cell types by anti-la alloantibodies is analyzed. Fc receptors and la alloantigens are clearly two distinct molecular entities. The association between Fc receptors and la alloantigens on a quantitative level seems to depend on a ligand-binding mechanism to control their interaction rather than the presence of a topographical molecular tandem arrangement.
- Subjects
LYMPHOCYTES; CELL receptors; IMMUNOGLOBULIN G; SERUM; BLOOD plasma; MACROPHAGES
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 5, p465
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb02104.x