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- Title
Therapy for Shigellosis. II. Randomized, Double-Blind Comparison of Ciprofloxacin and Ampicillin.
- Authors
Bennish, Michael L.; Salam, Mohammed A.; Haider, Rukhsana; Barza, Michael
- Abstract
Ciprofloxacin, 500 mg every 12 h, was compared withampicillin, 500 mg every 6 h, both given for 5 days, in the treatment of 121 adult males hospitalized with severe shigellosis. Treatment was randomized and double-blinded . At the completion of treatment, there was resolution or marked improvement in symptoms in 57 (95%) of 60 ciprofloxacin-treated patients, 23 (88%) of 26 ampicillin-treated patients infected with an ampicillin-susceptible strain of Shigella, and 15 (43%) of 35 ampicillin-treated patients infected with an ampicillin-resistant strain of Shigella (ampicillin-R group) (P < Al, ciprofloxacin or ampicillin groups vs. ampicillin-R group). Bacteriologic failure was less common (P < .025) in the ciprofloxacin group (0/60) than in the ampicillin (3/26,12%) or ampicillin-R groups (5/35,14%). Ciprofloxacin-treated patients had a mean of29 stools during the study, compared with 46 for ampicillin-treated patients (P = .004). Thus ciprofloxacin seems to be an effective, and perhaps superior, alternative to ampicillin in treating patients with shigellosis.
- Publication
Journal of Infectious Diseases, 1990, Vol 162, Issue 3, p711
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/162.3.711