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- Title
High frequency of BRAF mutations in nevi.
- Authors
Pollock, Pamela M.; Harper, Ursula L.; Hansen, Katherine S.; Yudt, Laura M.; Stark, Mitchell; Robbins, Christiane M.; Moses, Tracy Y.; Hostetter, Galen; Wagner, Urs; Kakareka, John; Salem, Ghadi; Pohida, Tom; Heenan, Peter; Duray, Paul; Kallioniemi, Olli; Hayward, Nicholas K.; Trent, Jeffrey M.; Meltzer, Paul S.
- Abstract
To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected melanoma and nevi samples. We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi. These data suggest that mutational activation of the RAS/RAF/MAPK pathway in nevi is a critical step in the initiation of melanocytic neoplasia but alone is insufficient for melanoma tumorigenesis.
- Subjects
NEVUS; MELANOMA; TUMORS
- Publication
Nature Genetics, 2003, Vol 33, Issue 1, p19
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1054