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- Title
Identification of functional and molecular bioinarkers in mildly hearing impaired subjects with and without tinnitus.
- Authors
Knipper, M.; Hofmeier, B.; Aldamer, E. S.; Walter, M.; Wolpert, S.; Ruttiger, L.; Ernemann, U.; Thiericke, J.; Klose, U.
- Abstract
Tinnitus is as a symptomatic malfunction of our hearing system, where phantom sounds are perceived without acoustic stimulation. Here we present a clinical pilot studies in hearing-impaired subjects with and without tinnitus that aimed to test our hypotheses in humans. We use audiometric measurements, the analysis of body fluids, and functional magnetic resonance tomography (fMRI)The results of this first pilot study in humans are discussed in the context of previous findings gained in animals. In recent years we have developed a fingerprint for tinnitus using a combination of behavior animal models for tinnitus and electrophysiological as well as molecular approaches in the peripheral and central auditory system. The characteristic features that distinguished equally hearing impaired animals with and without tinnitus are described through a failure to centrally maintain sound sensitivity after peripheral deprivation selectively in tinnitus animals (Knipper et al 2013, Prog. Biology; Ruttiger et al 2013, Singer et al 2013).
- Subjects
AUDIOMETRY; BIOMARKERS; BIOLOGICAL models; BODY fluids; ELECTROPHYSIOLOGY; HUMAN fingerprints; MAGNETIC resonance imaging; PILOT projects; TINNITUS
- Publication
Journal of Hearing Science, 2017, Vol 7, Issue 2, p107
- ISSN
2083-389X
- Publication type
Article