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- Title
Plasma Resistin Levels and Risk of Myocardial Infarction and Ischemic Stroke.
- Authors
Weikert, Cornelia; Westphal, Sabine; Berger, Klaus; Dierkes, Jutta; Möhlig, Matthias; Spranger, Joachim; Rimm, Eric B.; Willich, Stefan N.; Boeing, Heiner; Pischon, Tobias
- Abstract
Context: Resistin is a hormone that has been linked to insulin resistance, inflammatory processes, and coronary heart disease in case-control studies; however, prospective data on the association between plasma resistin levels and future risk of cardiovascular disease are lacking. Objective: The objective of the study was to investigate the association between plasma resistin levels and risk of future myocardial infarction (MI) and ischemic stroke (IS) in a large prospective cohort. Methods: We investigated the association between plasma resistin levels and risk of MI and IS in a case-cohort design among 26,490 middle-aged subjects from the European Investigation into Cancer and Nutrition-Potsdam Study without history of MI or stroke at time of blood draw. Plasma resistin levels were measured in baseline blood samples of 139 individuals who developed MI, 97 who developed IS, and 817 individuals who remained free of cardiovascular events during a mean follow-up of 6 yr. Results: After multivariable adjustment for established cardiovascular risk factors including C-reactive protein, individuals in the highest compared with the lowest quartile of plasma resistin levels had a significantly increased risk of MI (relative risk 2.09; 95% confidence interval 1.01– 4.31; P for trend 0.01). In contrast, plasma resistin levels were not significantly associated with risk of IS (relative risk 0.94; 95% confidence interval 0.51–1.73; P for trend 0.88). Conclusion: Our data suggest that high plasma resistin levels are associated with an increased risk of MI but not with risk of IS. Further studies are needed to evaluate the predictive value of plasma resistin levels for cardiovascular disease.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2008, Vol 93, Issue 7, p2647
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jc.2007-2735