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- Title
Usefulness of Thyrotropin (TSH)-Releasing Hormone Test and Nocturnal Surge of TSH for Diagnosis of Isolated Deficit of TSH Secretion.
- Authors
NORIYOSHI YAMAKITA; TAKASHI KOMAKI; TOSHIHIRO TAKAO; TOSHIHIRO MURAI; KOZO HASHIMOTO; KEIGO YASUDA
- Abstract
Six patients with idiopathic isolated deficit of TSH secretion were examined and reported on. Their clinical symptoms and routine biochemical data were unclear and were not specific for hypothyroidism. Serum triiodothyronine, free thyroxine and TSH levels were slightly low or low-normal. Basal metabolic rate and thyroidal 123I-uptake were also slightly low or low-normal. The response of serum TSH to TRH stimulation was blunted in all patients. No nocturnal surge of serum TSH level could be seen in any of the patients. Empty sella was revealed in three patients, and pituitary microadenoma in one patient via magnetic resolution imaging. Antihuman pituitary cytosol antibody was seen in five patients. Autoimmunity may have played a role in the pathogenesis of idiopathic isolated TSH deficiency. Routine examination of thyroid function cannot easily detect this disease. TSH response to TRH stimulation and nocturnal surge of TSH should be examined when this disease is suspected.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2001, Vol 86, Issue 3, p1054
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jcem.86.3.7267