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- Title
Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes.
- Authors
Meneilly, Graydon S.; McIntosh, Christopher H.S.; Pederson, Raymond A.; Habener, Joel F.; Ehlers, Mario R. W.; Egan, Josephine M.; Elahi, Dariush
- Abstract
<bold>Objective: </bold>To examine the insulinomimetic insulin-independent effects of glucagon-like peptide (GLP)-1 on glucose uptake in type 1 diabetic patients.<bold>Research Design and Methods: </bold>We used the hyperinsulinemic-euglycemic clamp (480 pmol. m(-2) x min(-1)) in paired randomized studies of six women and five men with type 1 diabetes. In the course of one of the paired studies, the subjects also received GLP-1 at a dose of 1.5 pmol. kg(-1) x min(-1). The patients were 41 +/- 3 years old with a BMI of 25 +/- 1 kg/m(2). The mean duration of diabetes was 23 +/- 3 years.<bold>Results: </bold>Plasma glucose was allowed to fall from a fasting level of approximately 11 mmol/l to 5.3 mmol/l in each study and thereafter was held stable at that level. Plasma insulin levels during both studies were approximately 900 pmol/l. Plasma C-peptide levels did not change during the studies. In the GLP-1 study, plasma total GLP-1 levels were elevated from the fasting level of 31 +/- 3 to 150 +/- 17 pmol/l. Plasma glucagon levels fell from the fasting levels of approximately 14 pmol/l to 9 pmol/l during both paired studies. Hepatic glucose production was suppressed during the glucose clamps in all studies. Glucose uptake was not different between the two studies ( approximately 40 micromol. kg(-1) x min(-1)).<bold>Conclusions: </bold>GLP-1 does not augment insulin-mediated glucose uptake in lean type 1 diabetic patients.
- Subjects
PEPTIDES; DIABETES; DRUG dosage; BLOOD sugar; C-peptide; CLINICAL trials; COMPARATIVE studies; GLUCAGON; HYPERINSULINISM; INSULIN; TYPE 1 diabetes; LIVER; RESEARCH methodology; MEDICAL cooperation; NEUROTRANSMITTERS; RESEARCH; GLUCAGON-like peptide 1; EVALUATION research; RANDOMIZED controlled trials; GLUCAGON-like peptides; GLUCOSE clamp technique
- Publication
Diabetes Care, 2003, Vol 26, Issue 3, p837
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.26.3.837