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- Title
Penetration of Ceftazidime Into Middle Ear Fluid in Children With Otitis Media With Effusion.
- Authors
Bégué, Pierre; Garabédian, Erea-Noël; Bertrand, Catherine; Aubert, Bernard; Chiche, Dan
- Abstract
Twenty-five children with otitis media with effusion received ceftazidime 50 mg/kg intravenously before bilateral myringotomy with insertion of tympanostomy tubes. Concentrations of ceftazidime measured in serum and middle ear fluid exceeded 4 mg/L (i.e., largely above the minimal inhibitory concentrations for the gram-negative pathogens commonly recovered from children with otitis media) for at least 4 hours. Mean peak concentrations occurred 30 to 90 minutes after the injection and reached 11 to 14 mg/L. These results are in keeping with the clinical efficacy of ceftazidime in the treatment of chronic middle ear infections in children.
- Publication
Laryngoscope, 1998, Vol 108, Issue 5, p662
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1097/00005537-199805000-00007