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- Title
Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: case report.
- Authors
Yamamoto, Daigo; Hamada, Yoshinori; Tsubota, Yu; Kawakami, Katsuhiro; Yamamoto, Chizuko; Yamamoto, Mitsuo
- Abstract
Background: Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers. Case presentation: We report a case of the coexistence of adenocarcinoma and gastrointestinal stromal tumor (GIST). Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvature of the proximal stomach and a submucosal nodule that measured about 3 cm in diameter in the lower part of the stomach body. Their pathological examination showed gastric cancer (poorly differentiated diffuse adenocarcinoma) and GIST (low-risk category). Further, immunohistochemical staining for C-kit and CD34 was positive, while that for SMA and S-100 was negative. Conclusion: Although it is not easy to speculate on the coexistence of adenocarcinoma and GIST, pre-and postoperative diagnoses may be essential, and such cancer development is not considered to be unusual.
- Subjects
GASTROINTESTINAL stromal tumors; ADENOCARCINOMA; GASTRIC diseases; CANCER patients; ENDOSCOPY
- Publication
World Journal of Surgical Oncology, 2012, Vol 10, Issue 1, p1
- ISSN
1477-7819
- Publication type
Case Study
- DOI
10.1186/1477-7819-10-6