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- Title
Association of depression with inflammation in hospitalized patients of myocardial Infarction.
- Authors
Yu-Xiu Shang; Wen-Qing Ding; Hong-Yan Qiu; Feng-Ping Zhu; Shu-Zhen Yan; Xue-Liang Wang
- Abstract
Objective: The aim of this study was to examine the associations between depression and inflammatory markers in patients admitted to the hospital for myocardial infarction. Methods: Inflammatory cytokines, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were assessed in a group of 75 depressed participants (score of ≥ 12) and compared to a control group of 75 nondepressed participants (score < 12), all who had been admitted to the hospital for myocardial infarction. The presence of depressive symptoms was assessed using the Beck Depressive Symptoms Inventory II Scale (BDI-II). Results: Depressed myocardial infarction participants had significantly greater levels of TNF-α (t = 2.070, P < 0.05) compared with control myocardial infarction participants. The BDI-II score was positively correlated with TNF-α levels (r = 0.222, P < 0.05). Conclusions: These results indicate that the presence of depressive symptoms is positively associated with TNF-α levels among patients who have suffered from myocardial infarction.
- Subjects
DEPRESSED persons; MYOCARDIAL infarction; INFLAMMATION; HOSPITAL patients; HOSPITAL admission &; discharge; PATIENTS; DIAGNOSIS
- Publication
Pakistan Journal of Medical Sciences, 2014, Vol 30, Issue 4, p692
- ISSN
1682-024X
- Publication type
Article
- DOI
10.12669/pjms.304.4584