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- Title
Malignant stromal cell tumor of the spleen in a WBN/Kob rat.
- Authors
Yui Terayama; Tetsuro Matsuura; Kiyokazu Ozaki
- Abstract
Primary splenic stromal tumors have rarely been reported in rodents. We report the case of a 90-week-old male WBN/Kob rat with a nodular demarcated mass in the spleen, which was kept as a non-treated animal in a long-term animal study. Histopathology revealed round to short spindle-shaped tumor cells arranged in a solid growth pattern. Invasive growth, anisokaryosis, and high mitotic activity (46 per 10 high-power fields [2.37 mm2]) were observed to be multifocal, but most tumor cells showed mild nuclear pleomorphism. The pattern of silver impregnation corresponded to that of the marginal zone of the red pulp. Immunohistochemistry revealed that the tumor cells were double positive for fascin and desmin and focally positive for Iba-1 and OX-6 expression. These characteristics were similar to those observed in fibroblastic reticular cells and dendritic cells in the marginal zone of the red pulp. These findings suggest that the malignant stromal cell tumor of the spleen in this case had characteristics of both fibroblastic reticular cells and dendritic cells.
- Subjects
CANCER cells; STROMAL cells; CELL tumors; SPLEEN; DENDRITIC cells
- Publication
Journal of Toxicologic Pathology, 2022, Vol 35, Issue 2, p205
- ISSN
0914-9198
- Publication type
Article
- DOI
10.1293/tox.2021-0067