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- Title
Actinomycin D as an Epimutagen in Protists.
- Authors
USPENSKAYA, Zoya I.; YUDIN, Alexander L.
- Abstract
A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as the inheritable destabilization of characters. A number of features indicate that this variation is epigenetic, that is, not caused by mutations in the DNA. Therefore, actinomycin D may be considered as an inducer of epigenetic inheritable changes, in other words, as an epimutagen.
- Subjects
AMOEBA proteus; DILEPTUS; DACTINOMYCIN; PROTISTA; GENETIC mutation
- Publication
Acta Protozoologica, 2017, Vol 56, Issue 3, p139
- ISSN
0065-1583
- Publication type
Article
- DOI
10.4467/16890027AP.17.012.7493