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- Title
Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
- Authors
Polikanov, Yury S; Melnikov, Sergey V; Söll, Dieter; Steitz, Thomas A
- Abstract
We report crystal structures of the Thermus thermophilus ribosome at 2.3- to 2.5-Å resolution, which have enabled modeling of rRNA modifications. The structures reveal contacts of modified nucleotides with mRNA and tRNAs or protein pY, and contacts within the ribosome interior stabilizing the functional fold of rRNA. Our work provides a resource to explore the roles of rRNA modifications and yields a more comprehensive atomic model of a bacterial ribosome.
- Subjects
THERMUS thermophilus; RIBOSOME structure; CRYSTAL structure research; NUCLEOTIDES; MESSENGER RNA
- Publication
Nature Structural & Molecular Biology, 2015, Vol 22, Issue 4, p342
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2992