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- Title
Prereplication-complex formation: a molecular double take?
- Authors
Yardimci, Hasan; Walter, Johannes C
- Abstract
In G1, two copies of the MCM2-7 helicase are recruited to each origin of replication. Whereas recruitment of the first MCM2-7 is likely to be analogous to the loading of sliding clamps around DNA, how the second MCM2-7 complex is recruited is highly contentious. Here, we argue that MCM2-7 loading involves specific modifications to the clamp-loading reaction and propose that the first and second MCM2-7 molecules are loaded via similar mechanisms.
- Subjects
DNA replication; DNA helicases; DNA-binding proteins; EUKARYOTIC cells; GENETIC regulation
- Publication
Nature Structural & Molecular Biology, 2014, Vol 21, Issue 1, p20
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2738