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- Title
Crystal structure of a monomeric retroviral protease solved by protein folding game players.
- Authors
Khatib, Firas; DiMaio, Frank; Cooper, Seth; Kazmierczyk, Maciej; Gilski, Miroslaw; Krzywda, Szymon; Zabranska, Helena; Pichova, Iva; Thompson, James; Popovi?, Zoran; Jaskolski, Mariusz; Baker, David
- Abstract
Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.
- Subjects
CRYSTALS; MONOMERS; RETROVIRUSES; PROTEOLYTIC enzymes; MOLECULES
- Publication
Nature Structural & Molecular Biology, 2011, Vol 18, Issue 10, p1175
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2119