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- Title
The effects of Melissa officinalis (lemon balm) in chronic stable angina on serum biomarkers of oxidative stress, inflammation and lipid profile.
- Authors
Ahmad Zare Javid; Haybar, Habib; Dehghan, Parvin; Mohammad Hosein Haghighizadeh; Seyede Marjan Mohaghegh; Ravanbakhsh, Maryam; Mohammadzadeh, Assieh; Javid, Ahmad Zare; Haghighizadeh, Mohammad Hosein; Mohaghegh, Seyede Marjan
- Abstract
<bold>Background and Objectives: </bold>Coronary artery disease (CAD) is a major cause of death worldwide. Chronic stable angina (CSA) is the primary sign of CAD. Oxidative stress and inflammation play a substantial role in pathogenesis and progression of CAD. The aim of this study was to investigate the effects of oral administration of powdered Melissa officinalis (MO) on biomarkers of oxidative stress, inflammation, and lipid profile in patients with CSA.<bold>Methods and Study Design: </bold>A randomized, double-blind, placebo-controlled clinical trial was performed in 80 patients with CSA. The subjects were randomly assigned to obtaineither oral MO 3 g/d (n=40) or placebo (n=40) for eight weeks. Anthropometric indices, biomarkers of oxidative stress, inflammation, and lipid profile were evaluated at baseline and post-intervention.<bold>Results: </bold>The mean serum concentrations of triglycerides, total-cholesterol, LDL-cholesterol, and malondialdehyde (MDA), and high sensitive C-Reactive Protein (hs-CRP) were lower in the intervention group compared with placebo (p<0.01) post intervention. Moreover, the mean serum concentration of paraxonase 1 (PNO1) and HDL-c were higher (p<0.001) in the intervention group compared with the control group.<bold>Conclusion: </bold>Oral MO supplementation improves the lipid profile, MDA, hs-CRP, and PNO1 in patients with CSA.
- Subjects
OXIDATIVE stress; CORONARY disease; LEMON balm; INFLAMMATION; MALONDIALDEHYDE
- Publication
Asia Pacific Journal of Clinical Nutrition, 2018, Vol 27, Issue 4, p785
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.022018.01