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- Title
Nickel-Catalyzed Decarboxylative Acylation of Heteroarenes by sp<sup>2</sup> CH Functionalization.
- Authors
Yang, Ke; Zhang, Cheng; Wang, Peng; Zhang, Yan; Ge, Haibo
- Abstract
Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids has been developed. This work represents the first example of decarboxylative cross-coupling reactions, in a CH bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Additionally, this approach provides an efficient access to azole ketones, an important structural motif in many medicinal compounds with a broad range of biological activities.
- Subjects
MOLECULAR structure of azoles; NICKEL spectra; DECARBOXYLATION; ACYLATION; SURFACE chemistry
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 24, p7241
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201402516