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- Title
Three‐dimensional inhomogeneous magnetization transfer with rapid gradient‐echo (3D ihMTRAGE) imaging.
- Authors
Varma, Gopal; Munsch, Fanny; Burns, Brian; Duhamel, Guillaume; Girard, Olivier M.; Guidon, Arnaud; Lebel, R. Marc; Alsop, David C.
- Abstract
Purpose: To demonstrate the feasibility of integrating the magnetization transfer (MT) preparations required for inhomogeneous MT (ihMT) within an MPRAGE‐style acquisition. Such a sequence allows for reduced power deposition and easy inclusion of other modules. Methods: An ihMT MPRAGE–style sequence (ihMTRAGE) was initially simulated to investigate acquisition of the 3D ihMT data sequentially, or in an interleaved manner. The ihMTRAGE sequence was implemented on a 3T clinical scanner to acquire ihMT data from the brain and spine. Results: Both simulations and in vivo data provided an ihMT signal that was significantly greater using a sequential ihMTRAGE acquisition, compared with an interleaved implementation. Comparison with a steady‐state ihMT acquisition (defined as having one MT RF pulse between successive acquisition modules) demonstrated how ihMTRAGE allows for a reduction in average power deposition, or greater ihMT signal at equal average power deposition. Inclusion of a prospective motion‐correction module did not significantly affect the ihMT signal obtained from regions of interest in the brain. The ihMTRAGE acquisition allowed combination with a spatial saturation module to reduce phase wrap artifacts in a cervical spinal cord acquisition. Conclusions: Use of preparations necessary for ihMT experiments within an MPRAGE‐style sequence provides a useful alternative for acquiring 3D ihMT data. Compared with our steady‐state implementation, ihMTRAGE provided reduced power deposition, while allowing use of the maximum intensity from off‐resonance RF pulses. The 3D ihMTRAGE acquisition allowed combination of other modules with the preparation necessary for ihMT experiments, specifically motion compensation and spatial saturation modules.
- Subjects
MAGNETIZATION transfer; SPINAL cord; CERVICAL cord
- Publication
Magnetic Resonance in Medicine, 2020, Vol 84, Issue 6, p2964
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.28324