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- Title
Higher plasma lipopolysaccharide concentrations are associated with less favorable phenotype in overweight/obese men.
- Authors
Moreira, Ana; Alves, Raquel; Teixeira, Tatiana; Macedo, Viviane; Oliveira, Leandro; Costa, Neuza; Bressan, Josefina; Carmo Gouveia Peluzio, Maria; Mattes, Richard; Cássia Gonçalves Alfenas, Rita
- Abstract
Purpose: Lipopolysaccharide (LPS) from the outer membrane of gram-negative bacteria might be an inflammation trigger in adipose tissue. It has recently been proposed that there is a link between adipose tissue distribution and blood LPS. However, the number of studies on this topic is scarce, and further investigation in humans is required. In this study, we explored the association between plasma LPS concentrations and body fat distribution, as well as the biochemical parameters that may indicate the presence of metabolic disorders. Methods: Sixty-seven young adult men with body mass index of 26-35 kg/m were evaluated. Anthropometry, body composition and body fat distribution, blood pressure, energy expenditure, physical activity level, dietary intake, and biochemical parameters were assessed. Results: Men with median plasma LPS ≥ 0.9 EU/mL presented higher sagittal abdominal diameter, trunk fat percentage, and android fat percentage, and mass, insulin and alanine aminotransferase concentrations, homeostasis model assessment of insulin resistance (HOMA-IR), and beta cell dysfunction (HOMA-B) than those with lower plasma LPS. LPS correlated positively with the trunk fat percentage, and android fat percentage, and mass, insulin, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase concentrations, as well as HOMA-IR and HOMA-B. Conclusion: Our results suggest that a higher plasma LPS concentration is associated with a less favorable phenotype as characterized by higher central adiposity, higher values of HOMA-IR, and beta cell function impairment in overweight/obese men.
- Subjects
BRAZIL; METABOLIC syndrome risk factors; BODY composition; ADIPOSE tissues; ALKALINE phosphatase; ASPARTATE aminotransferase; BLOOD testing; BLOOD pressure measurement; HUMAN body composition; CALORIMETRY; ENERGY metabolism; HOMEOSTASIS; INSULIN; INSULIN resistance; MATHEMATICS; MEN'S health; NUTRITIONAL assessment; OBESITY; QUESTIONNAIRES; RESEARCH evaluation; RESEARCH funding; STATISTICS; T-test (Statistics); PHENOTYPES; STATISTICAL power analysis; DATA analysis; ALANINE aminotransferase; BODY mass index; FOOD diaries; PHYSICAL activity; DATA analysis software; LIPOPOLYSACCHARIDES; DESCRIPTIVE statistics; ABDOMINAL adipose tissue; PHOTON absorptiometry; MANN Whitney U Test
- Publication
European Journal of Nutrition, 2015, Vol 54, Issue 8, p1363
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-014-0817-6