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- Title
The Clinical Impact of the Sum of the Maximum Standardized Uptake Value on the Pretreatment with F-FDG-PET/CT in Small-Cell Lung Cancer.
- Authors
Go, Se-Il; Song, Haa-Na; Kang, Jung-Hun; Kang, Myung Hee; Kim, Moon Jin; Jung, Jaehoon; Chung, Soon Il; Choi, Bong-Hoi; Hwang, In-Gyu; Kim, Seok-Hyun; Ling, Hui; Lee, Gyeong-Won
- Abstract
Objectives: The aim of this study was to investigate the clinical significance of the sum of the maximum standardized uptake value (sumSUVmax) on pretreatment positron emission tomography/computed tomography (18F-FDG-PET/CT) in newly diagnosed small-cell lung cancer (SCLC). Methods: We retrospectively analyzed 145 SCLC patients from March 2005 to June 2013 who underwent pretreatment 18F-FDG-PET/CT. The sumSUVmax was assessed in all malignant lesions up to a maximum of 5 lesions and a maximum of 2 lesions per organ according to RECIST 1.1. Results: A significant difference was found between the low and high sumSUVmax groups (low vs. high sumSUVmax, 91.5 vs. 77.3%; p = 0.018) in the response rate (RR) following frontline platinum-based chemotherapy. The group with low sumSUVmax showed significantly better overall survival (OS; p < 0.001) as well as better progression-free survival (PFS; p < 0.001) compared with the group with high sumSUVmax. Moreover, multivariate analysis revealed that a high sumSUVmax alone was an independent poor prognostic factor for OS (hazard ratio 2.676; 95% confidence interval, 1.674-4.277; p < 0.001). Conclusions: This study showed that the sumSUVmax adopted from RECIST 1.1 on pretreatment 18F-FDG PET/CT was significantly correlated with response to treatment, OS, and PFS in patients with SCLC. © 2013 S. Karger AG, Basel
- Subjects
DEOXY sugars; RADIOPHARMACEUTICALS; SMALL cell carcinoma; BLOOD testing; MEDICAL records; MULTIVARIATE analysis; PLATINUM; SURVIVAL; POSITRON emission tomography; PROPORTIONAL hazards models; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; LOG-rank test; THERAPEUTICS
- Publication
Oncology, 2014, Vol 86, Issue 1, p1
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000357136