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- Title
Multifocal Epstein-Barr Virus-Associated Smooth Muscle Tumor in Adults with AIDS: Case Report and Review of the Literature.
- Authors
Gallien, S.; Zuber, B.; Polivka, M.; Lagrange-Xelot, M.; Thiebault, J.-B.; Bertheau, P.; Gray, F.; Molina, J.-M.
- Abstract
Objectives: The aim of this study was to provide a systematic review of Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) in human immunodeficiency virus (HIV)-infected adults, focusing on clinical and histopathologic features and outcome. Methods: A literature search was performed using Medline, Embase and the Cochrane Library. Results: We reviewed 35 cases including our case of a patient with a progressive multifocal EBV-SMT. Patients were mainly men (n = 24) with a mean age of 35.5 years. Median CD4 count was 21/mm3. Main locations were brain (n = 12), liver (n = 8), spinal cord (n = 7) and adrenal gland (n = 6). The tumors were multifocal in 34% of cases, whereas analysis of clonality showed different clones in tumors from different sites. Treatment included removal surgery in 17 cases and/or radiotherapy in 9 and therapeutic abstention in 4. Mean follow-up after diagnosis was 12.3 months. Nine patients died during this period essentially from opportunistic infection and only 2 from the disease. Conclusion: EBV-SMT should be added to the list of virally induced tumors in severely immunocompromised HIV-infected adults. Multifocality of independent tumor clones, especially in liver, brain, spinal cord and adrenal gland, and a slow disease progression seem to be the key features of these tumors, the treatment of which remains poorly defined. Copyright © 2008 S. Karger AG, Basel
- Subjects
EPSTEIN-Barr virus diseases; SMOOTH muscle tumors; SARCOMA; HIV infections; HIV-positive persons
- Publication
Oncology, 2008, Vol 74, Issue 3/4, p167
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000151364