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- Title
Overexpression of c-ErbB-2 Protein in Gastric Cancer by Immunohistochemical Stain.
- Authors
Lee, Hye Ran; Kim, Joo-Hang; Uhm, Hyo Dong; Ahn, Joong Bae; Rha, Sun Young; Cho, Jae Yong; Lee, Jong In; Lee, Kyong Hee; Chung, Hyun Cheol; Roh, Jae Kyong; Min, Jin Sik; Lee, Kyong Sik; Shin, Dong Hwan; Kim, Byung Soo; Hong, Soon Won; Choi, Jin-Hyuk
- Abstract
An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery. Copyright © 1996 S. Karger AG, Basel
- Publication
Oncology, 1996, Vol 53, Issue 3, p192
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000227559