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- Title
Dermoscopic and Immunohistochemical Changes in Acquired Melanocytic Nevi following Narrow-Band Ultraviolet B Therapy.
- Authors
Zaher, Hesham; Bassiouny, Dalia; abdel Hay, Rania; Samir, Nesrin; Ragab, Nanees; Sayed, Safinaz
- Abstract
<bold>Background: </bold>Acquired melanocytic nevi (AMN) have been reported to undergo morphological and dermoscopic changes following exposure to narrow-band ultraviolet B (NB-UVB) radiation.<bold>Objective: </bold>To study the morphological, dermoscopic and immunohistochemical changes in AMN following NB-UVB radiation.<bold>Methods: </bold>Suberythemogenic NB-UVB sessions were delivered to 40 patients with AMN. For each patient, a minimum of 2 nevi were selected. One nevus was surgically removed from each patient prior to sessions as control; for the other nevus, dermoscopic images were captured before and after NB-UVB sessions. The images were evaluated for changes. At the end, another nevus was surgically removed for immunohistochemical assessment of Ki-67 and melan-A.<bold>Results: </bold>Our study showed a statistically significant increase in the size of AMN following NB-UVB radiation. Benign dermoscopic changes were observed. Statistically significant positive correlations were found between some dermoscopic findings and the total cumulative dose of NB-UVB. Immunohistochemical analysis did not show any significant change in the exposed AMN.<bold>Conclusion: </bold>AMN irradiated with repeated suberythemogenic doses of NB-UVB showed benign morphological and dermoscopic changes, and this was confirmed by our immunohistochemical study.
- Subjects
IMMUNOHISTOCHEMISTRY; DOSE-response relationship (Radiation); MICROSCOPY; MEDICAL radiology; NEVUS; SKIN; SKIN tumors; TUMOR antigens; TUMOR markers; ULTRAVIOLET radiation; SEVERITY of illness index; DIAGNOSIS
- Publication
Dermatology (10188665), 2016, Vol 232, Issue 3, p273
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000445780