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- Title
Current clinical issues in the management of herpes simplex virus infections in patients with HIV.
- Authors
Conant, M.
- Abstract
<bold>Background: </bold>A recent study done in Baltimore showed HSV-2 seroprevalence of 81% among 64 HIV-positive homosexual or bisexual men.<bold>Objective: </bold>Our purpose was to examine HSV-2 as a risk factor for acquiring HIV infection, as well as to explore the possibility that acyclovir, an agent that inhibits the replication or infectivity in herpesviruses, might have a survival benefit to patients with HIV infection.<bold>Methods: </bold>Studies were undertaken among HIV-positive patients to see if concomitant treatments including acyclovir offered a survival benefit.<bold>Results: </bold>A Multicenter AIDS Cohort Study held at four university-affiliated clinics and two landmark analyses demonstrated that acyclovir offered a significant survival advantage for HIV-positive patients. Another study had less conclusive results.<bold>Conclusion: </bold>Enough evidence of a survival benefit in HIV-positive patients on long-term acyclovir therapy warrants consideration of long-term prophylactic therapy with suppressive doses of acyclovir as routine intervention for HIV-positive patients.
- Subjects
ACYCLOVIR; ANTIVIRAL agents; HERPES genitalis prevention; HERPES simplex prevention; HERPES simplex transmission; BISEXUALITY; CHEMOPREVENTION; DRUG resistance in microorganisms; HERPES genitalis; HERPES simplex; HIV infections; HOMOSEXUALITY; LONGITUDINAL method; MEDICAL cooperation; RESEARCH; SURVIVAL; MICROBIAL virulence; AIDS-related opportunistic infections; HIV seroconversion; PREVENTION; INFECTIOUS disease transmission; THERAPEUTICS
- Publication
Dermatology (10188665), 1997, Vol 194, Issue 2, p93
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000246073