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- Title
Interleukin-6 and tumour necrosis factor levels decrease in the suction blister fluids of psoriatic patients during effective therapy.
- Authors
Ameglio, F; Bonifati, C; Pietravalle, M; Fazio, M
- Abstract
<bold>Background: </bold>Involvement of various cytokines in psoriasis pathomechanisms has previously been reported.<bold>Objective: </bold>To better define the relationship between the disease severity and interleukin-6 and tumour necrosis factor alpha skin levels, these two cytokines were measured in suction blister fluids obtained from involved and uninvolved skin areas of psoriatic patients treated with UVB, beta-methasone dipropionate and salicylic acid ointment.<bold>Methods: </bold>Determinations were performed by ELISA in fluids obtained from 6 patients with the Kiistala method, every 1-2 weeks for at least 1 month.<bold>Results: </bold>During the observation period, all the patients showed disease improvement (median PASI score declined from 13.4 to 3.9) and significant decreases in the cytokine levels in all samples.<bold>Conclusion: </bold>These results are in agreement with a functional involvement of these two cytokines in the pathogenesis of the disease and their possible use as follow-up markers.
- Subjects
PSORIASIS treatment; STEROID drugs; ANTI-inflammatory agents; BLISTERS; COMBINED modality therapy; EXUDATES &; transudates; GLUCOCORTICOIDS; INTERLEUKINS; LONGITUDINAL method; OINTMENTS; PSORIASIS; MEDICAL radiology; SALICYLATES; SALICYLIC acid; SKIN; STEROIDS; CUTANEOUS therapeutics; TUMOR necrosis factors; ULTRAVIOLET radiation; THERAPEUTICS
- Publication
Dermatology (10188665), 1994, Vol 189, Issue 4, p359
- ISSN
1018-8665
- Publication type
journal article