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- Title
Analysis of Monoterpenoid Indole Alkaloids Using Electrospray Ionization Tandem Mass Spectrometry.
- Authors
Li, Li-Mei; Li, Guo-You; Fang, Dong-Mei; Wu, Zhi-Jun; Zhang, Guo-Lin
- Abstract
Three representative monoterpenoid indole alkaloids isolated from the trunk barks of Winchia calophylla were investigated using electrospray quadrupole time-of-flight tandem mass spectrometry (ESI-QTOF-MS/MS) in positive-ion mode. The major CID-fragmentation patterns are the neutral losses of HO, CHNH (CHN or CHN), CHO, HCOOCH (HCOOH or CO), and CH molecules and CH radical. High-abundance radical ions at m/z 219, 217, and 205 are formed from corresponding precursor ions by loss of a CH radical. The product ion at m/z 168, 144, and 130 in the low-mass range are the characteristic ions of the indole part. A pair of isomers was distinguished unambiguously based on MS/MS spectra. The proposed fragmentation pathways were further supported by ESI-MS/MS/MS and D-labeling experiments.
- Subjects
ALKALOIDS; PLANT metabolites; HETEROCYCLIC compounds; MONOTERPENOIDS; TANDEM mass spectrometry
- Publication
Chemistry of Natural Compounds, 2015, Vol 51, Issue 1, p116
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-015-1215-x