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- Title
CT-DNA interaction, Fluorescence binding and Microbial activities of Schiff base ligand metal complexes derived from 4-bromobenzaldehyde and 2-amino-6-methylbenzothiazole.
- Authors
Senthamilselvan, G.; Palanimurugan, A.; Asma, B. Sithi; Cyril, A.
- Abstract
Bidentate ligand (L) was synthesized by knoevenagel reaction using 4-bromobenzaldehyde and 2-amino-6- methylbenzothiazole. The ligand has been confirmed from the analytical technique such as UV-Vis, FTIR, NMR, Mass and EPR spectral. The synthesized metal complexes were characterized from the spectra and physico-chemical techniques. These studies showed that the stoichiometric composition of ML2 type complexes. Absorption study implies that the compounds possess the octahedral geometry and their chelates are electrolytic and monomeric in nature. Absorption and gel electrophoresis experiments set up accepted the effective interaction with CT-DNA molecules. It was extended to Fluorescence emission study of binding. The anti-bacterial and antifungi studies were carried out by disc diffusion method. From the MIC values, metal complexes were controlling larger than Schiff base.
- Subjects
SCHIFF bases; LIGANDS (Chemistry); BENZOTHIAZOLE derivatives; GEL electrophoresis; DISC diffusion tests (Microbiology); STOICHIOMETRY
- Publication
Mapana Journal of Sciences, 2023, Vol 22, Issue 1, p147
- ISSN
0975-3303
- Publication type
Article
- DOI
10.12723/mjs.64.8