We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition.
- Authors
Verheul, Henk. M. W.; Pinedo, Herbert M.
- Abstract
Contrary to initial expectations, angiogenesis inhibitors can cause toxicities in patients with cancer. The toxicity profiles of these inhibitors reflect the disturbance of growth factor signalling pathways that are important for maintaining homeostasis. Experiences with angiogenesis inhibitors in clinical trials indicate that short-term toxicities are mostly manageable. However, these agents will also be given in prolonged treatment strategies, so we need to anticipate possible long-term toxicities. In addition, understanding the molecular mechanisms involved in the toxicity of angiogenesis inhibition should allow more specific and more potent inhibitors to be developed.
- Subjects
NEOVASCULARIZATION inhibitors; CANCER patients; CHEMICAL inhibitors; GROWTH factors; HOMEOSTASIS; CLINICAL trials; BLOOD platelets; VASCULAR endothelial growth factor antagonists; ANTINEOPLASTIC agents; BIOLOGICAL models; BLOOD coagulation; CELLULAR signal transduction; COMPARATIVE studies; DRUG resistance in cancer cells; DRUG administration; LEFT heart ventricle; HEART physiology; HYPERTENSION; RESEARCH methodology; MEDICAL cooperation; RESEARCH; THROMBOSIS; EVALUATION research; PHYSIOLOGY
- Publication
Nature Reviews Cancer, 2007, Vol 7, Issue 6, p475
- ISSN
1474-175X
- Publication type
research
- DOI
10.1038/nrc2152