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- Title
Impact of photoperiod on uterine redox/inflammatory and metabolic status of golden hamster, Mesocricetus auratus.
- Authors
Pal, Sriparna; Haldar, Chandana; Verma, Rakesh
- Abstract
Photoperiod modulates reproductive physiology at multiple levels in seasonally breeding animals. Golden hamsters are long‐day breeders that diminish their fertility during the short days. Photoperiod is known to regulate hormonal milieu and uterus is a hormone‐sensitive dynamic tissue. However, there is lack of molecular insight regarding the impact of photoperiod on uterine physiology with respect to redox and metabolic status in Mesocricetus auratus. We evaluated the impact of photoperiod on circulatory hormonal parameters (triiodothyronine [T3], thyroxin [T4], estradiol [E2], progesterone [P4], melatonin, and insulin), their receptor expressions and key markers associated with redox (SIRT‐1/FOXO‐1), inflammatory (NFĸB/COX‐2) and metabolic (IR/GLUT4) status in uterus. Adult female golden hamsters were exposed to different photoperiodic regimes, that is, short photoperiod (SP; 8L:16D) and long photoperiod (LP; 16L:8D) for 12 weeks. SP drastically decreased peripheral hormone profiles (T3, T4, E2, and P4) and compromised uterine histoarchitecture when compared with LP‐exposed hamsters. Further, SP markedly decreased thyroid hormone receptor‐α (TRα), insulin receptor, and glucose uptake transporter‐4 (GLUT‐4) expressions in uterus. We noted enhanced uterine oxidative (increased MDA and decreased SOD/CAT levels), SIRT‐1/FOXO‐1 expression and inflammatory (NFĸB/COX‐2) load in SP condition. Further, elevated levels of circulatory insulin, melatonin, and its receptor (MT‐1) expression in uterus was noted under SP condition. Thus, we may suggest that photoperiod might regulate uterine seasonality through modulation of local hormonal and redox/metabolic homeostasis thereby may restrict offspring bearing capacity under short days. Research Highlights: Photoperiod alters uterine histoarchitecture and redox balance.Photoperiod modulates uterine inflammatory and metabolic status.Short photoperiod upregulates uterine oxidative load.
- Subjects
GOLDEN hamster; OXIDATION-reduction reaction; INSULIN receptors; ANIMAL breeding; THYROID hormones; NONNUTRITIVE sweeteners
- Publication
Journal of Experimental Zoology: Part A Ecological & Integrative Physiology, 2022, Vol 337, Issue 8, p812
- ISSN
2471-5638
- Publication type
Article
- DOI
10.1002/jez.2638