We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Unbalanced estrogen metabolism in thyroid cancer.
- Authors
Zahid, Muhammad; Goldner, Whitney; Beseler, Cheryl L.; Rogan, Eleanor G.; Cavalieri, Ercole L.
- Abstract
Well-differentiated thyroid cancer most frequently occurs in premenopausal women. Greater exposure to estrogens may be a risk factor for thyroid cancer. To investigate the role of estrogens in thyroid cancer, a spot urine sample was obtained from 40 women with thyroid cancer and 40 age-matched controls. Thirty-eight estrogen metabolites, conjugates and DNA adducts were analyzed by using ultraperformance liquid chromatography/tandem mass spectrometry and the ratio of adducts to metabolites and conjugates was calculated for each sample. The ratio of depurinating estrogen-DNA adducts to estrogen metabolites and conjugates significantly differed between cases and controls ( p < 0.0001), demonstrating high specificity and sensitivity. These findings indicate that estrogen metabolism is unbalanced in thyroid cancer and suggest that formation of estrogen-DNA adducts might play a role in the initiation of thyroid cancer.
- Publication
International Journal of Cancer, 2013, Vol 133, Issue 11, p2642
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.28275