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- Title
Levels of nitric oxide, asymmetric dimethyl arginine, symmetric dimethyl arginine, and L-arginine in patients with obsessive-compulsive disorder.
- Authors
YILMAZ, Enver Demirel; ÜSTÜNDAĞ, Mehmet Fatih; GENÇER, Ali Görkem; KIVRAK, Yüksel; ÜNAL, Özge; BİLİCİ, Mustafa
- Abstract
Background/aim: We aimed to investigate and compare to healthy controls the variations in the levels of nitric oxide (NO), asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), and L-arginine levels in patients with obsessive-compulsive disorder (OCD). Materials and methods: We enrolled 30 patients with OCD and 30 healthy controls in the study consecutively. Diagnostic interviews of all participants were conducted with the Structured Clinical Interview for Axis I Disorders (SCID-I), and sociodemographic data of the participants were recorded. Patients scoring 10 points or more on the Yale-Brown Obsessive-Compulsive Scale were enrolled in the study. Results: The NO levels of patients with OCD were increased compared to the control group, but the increase was not statistically significant (P > 0.05). However, patients with OCD had significantly lower levels of ADMA, SDMA, and L-arginine compared with the controls (P < 0.001). Conclusion: We found a significant decrease in ADMA, SDMA, and L-arginine as NO inhibitors between the groups, possibly because of an increase in NO. However, the insignificant increase in NO suggests that ADMA, SDMA, and L-arginine play direct and potentially important roles in OCD biology.
- Subjects
ASYMMETRIC dimethylarginine; OBSESSIVE-compulsive disorder; NITRIC oxide; CLINICAL trials; MEDICAL statistics; PATIENTS
- Publication
Turkish Journal of Medical Sciences, 2016, Vol 46, Issue 3, p775
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-1503-100