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- Title
Up–Down Asymmetry of Cerebellar Activation During Vertical Pursuit Eye Movements.
- Authors
Glasauer, Stefan; Stephan, Thomas; Kalla, Roger; Marti, Sarah; Straumann, Dominik
- Abstract
Animal experiments have demonstrated that the vast majority of vertical gaze-velocity Purkinje cells in the cerebellar floccular lobe, whose firing rate is modulated during vertical smooth pursuit eye movements, show a preference for downward pursuit. Here we validate the functional vertical asymmetry of the cerebellar flocculus in humans using functional magnetic resonance imaging by demonstrating a significantly higher activation of the floccular lobe for downward than for upward pursuit. The findings corroborate our recent hypothesis on the pathogenesis of cerebellar downbeat nystagmus.
- Subjects
EYE movements; GAZE; PURKINJE cells; MAGNETIC resonance imaging; NYSTAGMUS
- Publication
Cerebellum, 2009, Vol 8, Issue 3, p385
- ISSN
1473-4222
- Publication type
Article
- DOI
10.1007/s12311-009-0109-5