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- Title
Association between IFN-γ +874 T/A (Rs2430561) Polymorphisms and Bipolar 1 Disorder: A Study in an Ethnic Iranian Population.
- Authors
Fatemi Nayeri, Mahdieh; Talaei, Ali; Tavakkol Afshari, Jalil; Reza Nikpoor, Amin; Talaei, Andisheh; Ganjali, Rashin
- Abstract
Background: The pathophysiology of bipolar 1 disorder (B1D), a major psychiatric disorder with inflammatory origins and structural changes in the brain, is of great interest to researchers. Pro-inflammatory biomarkers and specific gene expression play pivotal roles in B1D development, and IFN-γ has emerged as an important inflammatory marker. The aim of this research was to determine whether the INF-γ +874 T/A polymorphism is associated with B1D susceptibility in an ethnic Iranian population. Methods: The IFN-γ +874 T/A (rs2430561) gene polymorphism was studied in 106 B1D patients and 109 control subjects using sequence specific primers (SSPs) and amplification refractory mutation systempolymerase chain reaction (ARMS-PCR). Results: Significant statistical differences in IFN-γ +874 T/A polymorphism genotype distribution were found between the patients and control subjects (P = 0.0006). Decreased risk of B1D was detected in the codominant model (T/T vs T/A and A/A, OR = 0.19, 95% CI = 0.07-0.49 for T/A, OR = 0.38, 95% CI = 0.12-1.24 for A/A, P value=0.0006), and in the dominant model (T/T vs T/A-A/A, OR = 0.21, 95% CI = 0.08-0.54, P = 0.0005). However, no significant difference in the IFN-γ polymorphism allele distribution was found between the two groups (P = 0.25). Conclusions: The IFN-γ +874 T/A polymorphism may have a significant role in BID development.
- Subjects
BIPOLAR disorder; ETHNIC studies; GENE expression; MENTAL illness; INTERFERON gamma; SINGLE nucleotide polymorphisms
- Publication
Reports of Biochemistry & Molecular Biology, 2019, Vol 8, Issue 1, p1
- ISSN
2322-3480
- Publication type
Article