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- Title
Immune-mediated inflammatory diseases (IMIDs) in children: key research questions and some answers.
- Authors
Kallinich, Tilmann; Mall, Marcus A.
- Abstract
This document discusses immune-mediated inflammatory diseases (IMIDs) in children and adolescents. IMIDs are chronic disorders characterized by inflammation driven by immunological mechanisms that disrupt immune homeostasis. This can lead to acute inflammatory symptoms, tissue damage, and organ dysfunction. The factors driving IMIDs in children are still being researched, but environmental factors, obesity, low exposure to microbes, stress, and maternal exposure to infections or stress may play a role. The document also explores specific IMIDs such as systemic lupus erythematosus, juvenile dermatomyositis, and asthma, and discusses the importance of defining individual endotypes for personalized therapy. Overall, the document provides insights into the understanding of IMIDs in children and the potential for precision medicine in their treatment.
- Subjects
RESEARCH questions; B cells; REGULATORY B cells; REGULATORY T cells; ETIOLOGY of diseases; STILL'S disease; HOMEOSTASIS
- Publication
Molecular & Cellular Pediatrics, 2024, Vol 11, Issue 1, p1
- ISSN
2194-7791
- Publication type
Article
- DOI
10.1186/s40348-024-00177-7