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Engineering and crystal structure of a monomeric FLT3 ligand variant.
Published in:
Acta Crystallographica: Section F, Structural Biology Communications, 2021, v. 77, n. 4, p. 121, doi. 10.1107/S2053230X21003289
By:
- Pannecoucke, Erwin;
- Raes, Laurens;
- Savvides, Savvas N.
Publication type:
Article
The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Published in:
Nature Communications, 2022, v. 13, p. 1, doi. 10.1038/s41467-022-33764-1
By:
- Brinkhaus, Maximilian;
- Pannecoucke, Erwin;
- van der Kooi, Elvera J.;
- Bentlage, Arthur E. H.;
- Derksen, Ninotska I. L.;
- Andries, Julie;
- Balbino, Bianca;
- Sips, Magdalena;
- Ulrichts, Peter;
- Verheesen, Peter;
- de Haard, Hans;
- Rispens, Theo;
- Savvides, Savvas N.;
- Vidarsson, Gestur
Publication type:
Article
Attenuated CSF‐1R signalling drives cerebrovascular pathology.
Published in:
EMBO Molecular Medicine, 2021, v. 13, n. 2, p. 1, doi. 10.15252/emmm.202012889
By:
- Delaney, Conor;
- Farrell, Michael;
- Doherty, Colin P;
- Brennan, Kiva;
- O'Keeffe, Eoin;
- Greene, Chris;
- Byrne, Kieva;
- Kelly, Eoin;
- Birmingham, Niamh;
- Hickey, Paula;
- Cronin, Simon;
- Savvides, Savvas N;
- Doyle, Sarah L;
- Campbell, Matthew
Publication type:
Article
Clostridium perfringens chitinases, key enzymes during early stages of necrotic enteritis in broiler chickens.
Published in:
PLoS Pathogens, 2024, v. 20, n. 9, p. 1, doi. 10.1371/journal.ppat.1012560
By:
- Dierick, Evelien;
- Callens, Chana;
- Bloch, Yehudi;
- Savvides, Savvas N.;
- Hark, Sarah;
- Pelzer, Stefan;
- Ducatelle, Richard;
- Van Immerseel, Filip;
- Goossens, Evy
Publication type:
Article
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Published in:
Nucleic Acids Research, 2014, v. 42, n. 15, p. 1, doi. 10.1093/nar/gku665
By:
- Yurong Wen;
- Behiels, Ester;
- Felix, Jan;
- Elegheert, Jonathan;
- Vergauwen, Bjorn;
- Devreese, Bart;
- Savvides, Savvas N.
Publication type:
Article
Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23314-6
By:
- Yperman, Klaas;
- Papageorgiou, Anna C.;
- Merceron, Romain;
- De Munck, Steven;
- Bloch, Yehudi;
- Eeckhout, Dominique;
- Jiang, Qihang;
- Tack, Pieter;
- Grigoryan, Rosa;
- Evangelidis, Thomas;
- Van Leene, Jelle;
- Vincze, Laszlo;
- Vandenabeele, Peter;
- Vanhaecke, Frank;
- Potocký, Martin;
- De Jaeger, Geert;
- Savvides, Savvas N.;
- Tripsianes, Konstantinos;
- Pleskot, Roman;
- Van Damme, Daniel
Publication type:
Article
Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2.
Published in:
EMBO Journal, 2024, v. 43, n. 5, p. 695, doi. 10.1038/s44318-023-00015-y
By:
- Cloots, Eva;
- Guilbert, Phaedra;
- Provost, Mathias;
- Neidhardt, Lisa;
- Van de Velde, Evelien;
- Fayazpour, Farzaneh;
- De Sutter, Delphine;
- Savvides, Savvas N;
- Eyckerman, Sven;
- Janssens, Sophie
Publication type:
Article
Structural basis of the proinflammatory signaling complex mediated by TSLP.
Published in:
Nature Structural & Molecular Biology, 2014, v. 21, n. 4, p. 375, doi. 10.1038/nsmb.2794
By:
- Verstraete, Kenneth;
- van Schie, Loes;
- Vyncke, Laurens;
- Bloch, Yehudi;
- Tavernier, Jan;
- Pauwels, Ewald;
- Peelman, Frank;
- Savvides, Savvas N
Publication type:
Article
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.
Published in:
Nature Structural & Molecular Biology, 2012, v. 19, n. 9, p. 938, doi. 10.1038/nsmb.2367
By:
- Elegheert, Jonathan;
- Bracke, Nathalie;
- Pouliot, Philippe;
- Gutsche, Irina;
- Shkumatov, Alexander V;
- Tarbouriech, Nicolas;
- Verstraete, Kenneth;
- Bekaert, Anaïs;
- Burmeister, Wim P;
- Svergun, Dmitri I;
- Lambrecht, Bart N;
- Vergauwen, Bjorn;
- Savvides, Savvas N
Publication type:
Article
Structure of a membrane-based steric chaperone in complex with its lipase substrate.
Published in:
Nature Structural & Molecular Biology, 2006, v. 13, n. 4, p. 374, doi. 10.1038/nsmb1065
By:
- Pauwels, Kris;
- Lustig, Ariel;
- Wyns, Lode;
- Tommassen, Jan;
- Savvides, Savvas N;
- Van Gelder, Patrick
Publication type:
Article
A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation.
Published in:
Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.02366
By:
- De Bruyne, Marieke;
- Hoste, Levi;
- Bogaert, Delfien J.;
- Van den Bossche, Lien;
- Tavernier, Simon J.;
- Parthoens, Eef;
- Migaud, Mélanie;
- Konopnicki, Deborah;
- Jean Cyr Yombi;
- Lambrecht, Bart N.;
- van Daele, Sabine;
- de Medeiros, Ana Karina Alves;
- Brochez, Lieve;
- Beyaert, Rudi;
- De Baere, Elfride;
- Puel, Anne;
- Casanova, Jean-Laurent;
- Goffard, Jean-Christophe;
- Savvides, Savvas N.;
- Haerynck, Filomeen
Publication type:
Article
Improving de novo protein binder design with deep learning.
Published in:
Nature Communications, 2023, p. 1, doi. 10.1038/s41467-023-38328-5
By:
- Bennett, Nathaniel R.;
- Coventry, Brian;
- Goreshnik, Inna;
- Huang, Buwei;
- Allen, Aza;
- Vafeados, Dionne;
- Peng, Ying Po;
- Dauparas, Justas;
- Baek, Minkyung;
- Stewart, Lance;
- DiMaio, Frank;
- De Munck, Steven;
- Savvides, Savvas N.;
- Baker, David
Publication type:
Article
Construction of cellobiose phosphorylase variants with broadened acceptor specificity towards anomerically substituted glucosides.
Published in:
Biotechnology & Bioengineering, 2010, v. 107, n. 3, p. 413, doi. 10.1002/bit.22818
By:
- De Groeve, Manu R.M.;
- Remmery, Laurens;
- Van Hoorebeke, Annelies;
- Stout, Jan;
- Desmet, Tom;
- Savvides, Savvas N.;
- Soetaert, Wim
Publication type:
Article
Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer.
Published in:
Frontiers in Immunology, 2020, v. 11, p. 1, doi. 10.3389/fimmu.2020.01557
By:
- Marković, Iva;
- Savvides, Savvas N.
Publication type:
Article
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors.
Published in:
Frontiers in Immunology, 2020, v. 11, p. 1, doi. 10.3389/fimmu.2020.01422
By:
- Holgado, Aurora;
- Braun, Harald;
- Verstraete, Kenneth;
- Vanneste, Domien;
- Callewaert, Nico;
- Savvides, Savvas N.;
- Afonina, Inna S.;
- Beyaert, Rudi
Publication type:
Article
Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans.
Published in:
Molecular Microbiology, 2013, v. 89, n. 2, p. 288, doi. 10.1111/mmi.12274
By:
- Vergauwen, Bjorn;
- Verstraete, Kenneth;
- Senadheera, Dilani B.;
- Dansercoer, Ann;
- Cvitkovitch, Dennis G.;
- Guédon, Eric;
- Savvides, Savvas N.
Publication type:
Article
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09667-z
By:
- Slowicka, Karolina;
- Serramito-Gómez, Inmaculada;
- Boada-Romero, Emilio;
- Martens, Arne;
- Sze, Mozes;
- Petta, Ioanna;
- Vikkula, Hanna K.;
- De Rycke, Riet;
- Parthoens, Eef;
- Lippens, Saskia;
- Savvides, Savvas N.;
- Wullaert, Andy;
- Vereecke, Lars;
- Pimentel-Muiños, Felipe X.;
- van Loo, Geert
Publication type:
Article
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09690-0
By:
- Dondelinger, Yves;
- Delanghe, Tom;
- Priem, Dario;
- Wynosky-Dolfi, Meghan A.;
- Sorobetea, Daniel;
- Rojas-Rivera, Diego;
- Giansanti, Piero;
- Roelandt, Ria;
- Gropengiesser, Julia;
- Ruckdeschel, Klaus;
- Savvides, Savvas N.;
- Heck, Albert J. R.;
- Vandenabeele, Peter;
- Brodsky, Igor E.;
- Bertrand, Mathieu J. M.
Publication type:
Article
Ym1 protein crystals promote type 2 immunity.
Published in:
eLife, 2024, p. 1, doi. 10.7554/eLife.90676
By:
- Heyndrickx, Ines;
- Deswarte, Kim;
- Verstraete, Kenneth;
- Verschueren, Koen H. G.;
- Smole, Ursula;
- Aegerter, Helena;
- Dansercoer, Ann;
- Hammad, Hamida;
- Savvides, Savvas N.;
- Lambrecht, Bart N.
Publication type:
Article
Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference.
Published in:
FEBS Journal, 2013, v. 280, n. 5, p. 1358, doi. 10.1111/febs.12128
By:
- Buysschaert, Géraldine;
- Verstraete, Kenneth;
- Savvides, Savvas N.;
- Vergauwen, Bjorn
Publication type:
Article
Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33.
Published in:
Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.582044
By:
- Teufelberger, Andrea R.;
- Van Nevel, Sharon;
- Hulpiau, Paco;
- Nordengrün, Maria;
- Savvides, Savvas N.;
- De Graeve, Sarah;
- Akula, Srinivas;
- Holtappels, Gabriele;
- De Ruyck, Natalie;
- Declercq, Wim;
- Vandenabeele, Peter;
- Hellman, Lars;
- Bröker, Barbara M.;
- Krysko, Dmitri V.;
- Bachert, Claus;
- Krysko, Olga
Publication type:
Article
Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress.
Published in:
Environmental Microbiology, 2017, v. 19, n. 10, p. 3930, doi. 10.1111/1462-2920.13793
By:
- Devos, Simon;
- Van Putte, Wouter;
- Vitse, Jolien;
- Van Driessche, Gonzalez;
- Stremersch, Stephan;
- Van Den Broek, Wim;
- Raemdonck, Koen;
- Braeckmans, Kevin;
- Stahlberg, Henning;
- Kudryashev, Misha;
- Savvides, Savvas N.;
- Devreese, Bart
Publication type:
Article
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Published in:
Nature Communications, 2017, v. 8, n. 4, p. 14937, doi. 10.1038/ncomms14937
By:
- Verstraete, Kenneth;
- Peelman, Frank;
- Braun, Harald;
- Lopez, Juan;
- Van Rompaey, Dries;
- Dansercoer, Ann;
- Vandenberghe, Isabel;
- Pauwels, Kris;
- Tavernier, Jan;
- Lambrecht, Bart N.;
- Hammad, Hamida;
- De Winter, Hans;
- Beyaert, Rudi;
- Lippens, Guy;
- Savvides, Savvas N.
Publication type:
Article
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Published in:
Nature Communications, 2016, v. 7, n. 11, p. 13228, doi. 10.1038/ncomms13228
By:
- Felix, Jan;
- Kandiah, Eaazhisai;
- De Munck, Steven;
- Bloch, Yehudi;
- van Zundert, Gydo C.P.;
- Pauwels, Kris;
- Dansercoer, Ann;
- Novanska, Katka;
- Read, Randy J.;
- Bonvin, Alexandre M.J.J.;
- Vergauwen, Bjorn;
- Verstraete, Kenneth;
- Gutsche, Irina;
- Savvides, Savvas N.
Publication type:
Article
Structural basis of IL-23 antagonism by an Alphabody protein scaffold.
Published in:
Nature Communications, 2014, v. 5, n. 10, p. 5237, doi. 10.1038/ncomms6237
By:
- Desmet, Johan;
- Verstraete, Kenneth;
- Bloch, Yehudi;
- Lorent, Eric;
- Wen, Yurong;
- Devreese, Bart;
- Vandenbroucke, Karen;
- Loverix, Stefan;
- Hettmann, Thore;
- Deroo, Sabrina;
- Somers, Klaartje;
- Henderikx, Paula;
- Lasters, Ignace;
- Savvides, Savvas N.
Publication type:
Article
Structure of Hemocyanin Subunit CaeSS2 of the Crustacean Mediterranean Crab Carcinus aestuarii.
Published in:
Journal of Biochemistry, 2005, v. 138, n. 3, p. 303, doi. 10.1093/jb/mvi130
By:
- Dolashka-Angelova, Pavlina;
- Dolashki, Alexandar;
- Savvides, Savvas N.;
- Hristova, Rumyana;
- Van Beeumen, Jozef;
- Voelter, Wolfgang;
- Devreese, Bart;
- Weser, Ulrich;
- Di Muro, Paolo;
- Salvato, Benedetto;
- Stevanovic, Stefan
Publication type:
Article
Homogeneously N‐glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction‐quality crystallogenesis.
Published in:
Acta Crystallographica: Section D, Structural Biology, 2020, v. 76, n. 12, p. 1244, doi. 10.1107/S2059798320013753
By:
- Kozak, Sandra;
- Bloch, Yehudi;
- De Munck, Steven;
- Mikula, Aleksandra;
- Bento, Isabel;
- Savvides, Savvas N.;
- Meijers, Rob
Publication type:
Article
Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
Published in:
Nature Structural Biology, 2000, v. 7, n. 6, p. 486, doi. 10.1038/75896
By:
- Savvides, Savvas N.;
- Boone, Tom;
- Andrew Karplus, P.
Publication type:
Article
Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands.
Published in:
FEBS Letters, 2017, v. 591, n. 20, p. 3391, doi. 10.1002/1873-3468.12833
By:
- Elegheert, Jonathan;
- Brigé, Ann;
- Van Beeumen, Jozef;
- Savvides, Savvas N.
Publication type:
Article
The Charcot–Leyden crystal protein galectin‐10 is not a major determinant of human regulatory T‐cell function.
Published in:
Allergy, 2022, v. 77, n. 9, p. 2818, doi. 10.1111/all.15332
By:
- Arroyo‐Hornero, Rebeca;
- Aegerter, Helena;
- Hamad, Ibrahim;
- Corte‐Real, Beatriz;
- Staes, Katrien;
- van der Woning, Bas;
- Verstraete, Kenneth;
- Savvides, Savvas N.;
- Lambrecht, Bart N.;
- Kleinewietfeld, Markus
Publication type:
Article
Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins.
Published in:
Glycobiology, 2021, v. 31, n. 8, p. 1005, doi. 10.1093/glycob/cwab027
By:
- Robakiewicz, Stefania;
- Bridot, Clarisse;
- Serna, Sonia;
- Gimeno, Ana;
- Echeverria, Begoña;
- Delgado, Sandra;
- Ruyck, Jérôme de;
- Semwal, Shubham;
- Charro, Diego;
- Dansercoer, Ann;
- Verstraete, Kenneth;
- Azkargorta, Mikel;
- Noort, Kim van;
- Wilbers, Ruud H P;
- Savvides, Savvas N;
- Abrescia, Nicola G A;
- Arda, Ana;
- Reichardt, Niels C;
- Jiménez-Barbero, Jesús;
- Bouckaert, Julie
Publication type:
Article
Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34956-w
By:
- Fulara, Aleksandra;
- Vandenberghe, Isabel;
- Read, Randy J.;
- Devreese, Bart;
- Savvides, Savvas N.
Publication type:
Article
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance.
Published in:
Genome Biology, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s13059-020-02087-z
By:
- D'Anna, Flora;
- Van Dyck, Laurien;
- Xiong, Jieyi;
- Zhao, Hui;
- Berrens, Rebecca V.;
- Qian, Junbin;
- Bieniasz-Krzywiec, Pawel;
- Chandra, Vikas;
- Schoonjans, Luc;
- Matthews, Jason;
- De Smedt, Julie;
- Minnoye, Liesbeth;
- Amorim, Ricardo;
- Khorasanizadeh, Sepideh;
- Yu, Qian;
- Zhao, Liyun;
- De Borre, Marie;
- Savvides, Savvas N.;
- Simon, M. Celeste;
- Carmeliet, Peter
Publication type:
Article
X-ray crystallographic analysis of the sulfur carrier protein SoxY from Chlorobium limicola f. thiosulfatophilum reveals a tetrameric structure.
Published in:
Protein Science: A Publication of the Protein Society, 2007, v. 16, n. 4, p. 589, doi. 10.1110/ps.062633607
By:
- Stout, Jan;
- Van Driessche, Gonzalez;
- Savvides, Savvas N.;
- Van Beeumen, Jozef
Publication type:
Article
The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA.
Published in:
Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 7, p. 1942, doi. 10.1110/ps.04661904
By:
- Savvides, Savvas N.;
- Raghunathan, Srinivasan;
- Fütterer, Klaus;
- Kozlov, Alex G.;
- Lohman, Timothy M.;
- Waksman, Gabriel
Publication type:
Article
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.
Published in:
2012
By:
- Verstraete K;
- Savvides SN;
- Verstraete, Kenneth;
- Savvides, Savvas N
Publication type:
journal article
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.
Published in:
Nature Reviews Cancer, 2012, v. 12, n. 11, p. 753, doi. 10.1038/nrc3371
By:
- Verstraete, Kenneth;
- Savvides, Savvas N.
Publication type:
Article
Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45324-8
By:
- Van Damme, Karel F. A.;
- Hertens, Pieter;
- Martens, Arne;
- Gilis, Elisabeth;
- Priem, Dario;
- Bruggeman, Inge;
- Fossoul, Amelie;
- Declercq, Jozefien;
- Aegerter, Helena;
- Wullaert, Andy;
- Hochepied, Tino;
- Hoste, Esther;
- Vande Walle, Lieselotte;
- Lamkanfi, Mohamed;
- Savvides, Savvas N.;
- Elewaut, Dirk;
- Lambrecht, Bart N.;
- van Loo, Geert
Publication type:
Article
Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45324-8
By:
- Van Damme, Karel F. A.;
- Hertens, Pieter;
- Martens, Arne;
- Gilis, Elisabeth;
- Priem, Dario;
- Bruggeman, Inge;
- Fossoul, Amelie;
- Declercq, Jozefien;
- Aegerter, Helena;
- Wullaert, Andy;
- Hochepied, Tino;
- Hoste, Esther;
- Vande Walle, Lieselotte;
- Lamkanfi, Mohamed;
- Savvides, Savvas N.;
- Elewaut, Dirk;
- Lambrecht, Bart N.;
- van Loo, Geert
Publication type:
Article
Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45324-8
By:
- Van Damme, Karel F. A.;
- Hertens, Pieter;
- Martens, Arne;
- Gilis, Elisabeth;
- Priem, Dario;
- Bruggeman, Inge;
- Fossoul, Amelie;
- Declercq, Jozefien;
- Aegerter, Helena;
- Wullaert, Andy;
- Hochepied, Tino;
- Hoste, Esther;
- Walle, Lieselotte Vande;
- Lamkanfi, Mohamed;
- Savvides, Savvas N.;
- Elewaut, Dirk;
- Lambrecht, Bart N.;
- van Loo, Geert
Publication type:
Article
Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris.
Published in:
Biological Chemistry, 2014, v. 395, n. 4, p. 413, doi. 10.1515/hsz-2013-0267
By:
- Al Atalah, Bassam;
- Vanderschaeghe, Dieter;
- Bloch, Yehudi;
- Proost, Paul;
- Plas, Kirsten;
- Callewaert, Nico;
- Savvides, Savvas N.;
- Van Damme, Els J.M.
Publication type:
Article

Found: 41