We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relationship of Fibroblast Growth Factor 23 Serum Levels with Disease Characteristics in Systemic Lupus Erythematosus Patients.
- Authors
Fernández-Cladera, Yolanda; Gómez-Bernal, Fuensanta; García-González, María; Quevedo-Abeledo, Juan C.; González-Rivero, Agustín F.; de Vera-González, Antonia; Martín-González, Candelaria; Nunes-Andrade, Ana L.; López-Mejías, Raquel; González-Gay, Miguel Á.; Ferraz-Amaro, Iván
- Abstract
Fibroblast growth factor 23 (FGF23), a hormone secreted by osteocytes and osteoblasts, is a major regulator of vitamin D and phosphate homeostasis. FGF23 has been associated with the disturbance of mineral homeostasis, and with kidney and cardiovascular diseases. Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect virtually any organ. In the present work, we set out to analyze the relationship of FGF23 with the expression of SLE, including patterns of activity, damage, and severity. A total of 284 well-characterized patients with SLE were recruited. Activity (SLEDAI), severity (Katz), and damage index (SLICC-DI) scores were determined. The serum levels of FGF23 were also assessed. Multivariable linear regression analysis was performed to study the relationship between disease characteristics and FGF23. FGF23 and 25(OH) vitamin D were negatively correlated. Furthermore, prednisone use was associated with higher circulating FGF23 after an adjustment for confounding factors. SLICC-DI was related to higher serum levels of FGF23 after a multivariable analysis. However, when the SLICC-DI index items and domains were analyzed separately, apart from proteinuria ≥3.5 gm/24 h, only the musculoskeletal domain, encompassing arthritis and osteoporosis, was significantly associated with higher serum levels of FGF23. In conclusion, an association is observed between elevated serum FGF23 levels and disease damage, particularly related to musculoskeletal complications and proteinuria, in patients with SLE.
- Subjects
SYSTEMIC lupus erythematosus; FIBROBLAST growth factors; HOMEOSTASIS; AUTOIMMUNE diseases; VITAMIN D
- Publication
Biomolecules (2218-273X), 2023, Vol 13, Issue 8, p1222
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom13081222