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- Title
Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells.
- Authors
Ngo, Dai Hung; Ngo, Dai Nghiep; Kim, Se-Kwon; Vo, Thanh Sang
- Abstract
The aminoethyl–chitooligosaccharide (AE-COS) was reported to inhibit human gastric cancer cell proliferation and human fibrosarcoma cell invasion. In this study, the role of AE-COS in down-regulation of proliferation of human lung A549 cancer cells was evaluated. It was found that AE-COS was able to reduce A549 cell proliferation to (32 ± 1.3)% at a concentration of 500 µg/mL. Moreover, AE-COS treatment caused suppression on COX-2 expression in a dose-dependent manner. Notably, the role of AE-COS in induction of cell apoptosis was observed via decreasing Bcl-2 expression and increasing caspase-3 and -9 activation. Accordingly, the antiproliferative effect of AE-COS was indicated due to suppression of cell proliferation and induction of cell apoptosis, suggesting AE-COS as a promising chemotherapy agent for treatment of lung cancer.
- Subjects
CANCER cells; LUNG cancer; CANCER cell proliferation; CELL proliferation; STOMACH cancer
- Publication
Biomolecules (2218-273X), 2019, Vol 9, Issue 5, p195
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom9050195