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- Title
Immune Responses Against Helicobacter pylori in Gastric Cancer Patients and in Risk Groups for Gastric Cancer.
- Authors
Adamsson, Jenni; Lundin, Samuel B.; Hansson, Lars‐Erik; Sjövall, Henrik; Svennerholm, Ann‐Mari
- Abstract
Background It has previously been reported that weak serum Ig G but elevated Ig A antibody responses against H. pylori may be associated with risk of gastric cancer ( GC) development. To search for potential immunologic markers for GC, we analyzed antibody responses against H. pylori in risk groups of cancer development. Material and Methods Sera and stomach biopsies collected from H. pylori-infected GC patients as well as from patients with gastric ulcer ( GU), atrophic gastritis, intestinal metaplasia ( IM) and duodenal ulcer and from H. pylori-infected control subjects without atrophy or IM, and in addition from H. pylori-negative subjects were analyzed for Ig G and Ig A antibodies against three different H. pylori antigen preparations, that is, membrane protein ( MP), urease, and Cag A. Results We observed an increased serum Ig A/ Ig G titer ratio against H. pylori anti- MP in GC and GU patients, and against Cag A in Hp-infected GC patients and risk groups. Female patients with GC had a higher serum anti- MP Ig A/ Ig G titer ratio and a higher proportion of poorly differentiated cancer compared with male patients. As earlier observed, the non-tumorous mucosa of H. pylori-infected GC patients contained considerably lower levels of total Ig A and H. pylori-specific Ig A compared with H. pylori-infected controls. Similarly, we observed decreased specific mucosal anti- MP Ig A response in patients with IM. Conclusion We observed several differences in local and systemic immunologic responses against H. pylori in H. pylori-infected GC patients and putative GC risk group patients compared with H. pylori-infected controls. These findings may be of importance in efforts to identify risk groups of GC or early stages of GC.
- Subjects
ANTIBODY formation; GASTRIC mucosa; CANCER patients; HELICOBACTER pylori; METAPLASIA; CANCER
- Publication
Helicobacter, 2013, Vol 18, Issue 1, p73
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1111/j.1523-5378.2012.00991.x