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- Title
Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease.
- Authors
Bridoux, Agathe; Moutereau, Stephane; Covali-Noroc, Ala; Margarit, Laurent; Palfi, Stephane; Nguyen, Jean-Paul; Lefaucheur, Jean-Pascal; Césaro, Pierre; d'Ortho, Marie-Pia; Xavier Drouot
- Abstract
Objective: Patients with Parkinson's disease frequently complain of sleep disturbances and loss of muscle atonia during rapid-eye-movement (REM) sleep is not rare. The orexin-A (hypocretin-1) hypothalamic system plays a central role in controlling REM sleep. Loss of orexin neurons results in narcolepsy-cataplexy, a condition characterized by diurnal sleepiness and REM sleep without atonia. Alterations in the orexin-A system have been also documented in Parkinson's disease, but whether these alterations have clinical consequences remains unknown. Methods: Here, we measured orexin-A levels in ventricular cerebrospinal fluid from eight patients with Parkinson's disease (four males and four females) who underwent ventriculography during deep brain-stimulation surgery and performed full-night polysomnography before surgery. Results: Our results showed a positive correlation between orexin-A levels and REM sleep without muscle atonia. Conclusion: Our results suggest that high levels of orexin-A in Parkinson's disease may be associated with loss of REM muscle atonia.
- Subjects
HYPOTHALAMIC hormones; CEREBROSPINAL fluid; PARKINSON'S disease; SLEEP disorders; OREXINS; NARCOLEPSY; CATAPLEXY
- Publication
Nature & Science of Sleep, 2013, Vol 5, p87
- ISSN
1179-1608
- Publication type
Article
- DOI
10.2147/NSS.S41245