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- Title
Utility of IgE (total and Aspergillus fumigatus specific) in monitoring for response and exacerbations in allergic bronchopulmonary aspergillosis.
- Authors
Agarwal, Ritesh; Aggarwal, Ashutosh N.; Sehgal, Inderpaul S.; Dhooria, Sahajal; Behera, Digambar; Chakrabarti, Arunaloke
- Abstract
The role of total and specific IgE in monitoring treatment responses in allergic bronchopulmonary aspergillosis ( ABPA) remains poorly studied. Here in, we evaluate the utility of total and Aspergillus fumigatus specific IgE in the follow-up of ABPA. Eighty-one consecutive treatment-naïve patients of ABPA (acute stage) with pulmonary infiltrates and bronchiectasis underwent measurement of total and A. fumigatus specific IgE at baseline, after 8 weeks of glucocorticoid therapy, and during exacerbations. There was clinical and radiological improvement after treatment with median decline of total IgE by 51.9%. The total IgE declined by at least 35%, 25% and 20% in 69 (85.2%), 76 (93.6%) and 78 (96.3%) patients, respectively. On the other hand, the A. fumigatus specific IgE increased in 42 (51.9%) subjects, and the mean increase was 1.4%, after 8 weeks. Among 13 patients with exacerbation, 12 (92.3%) had a rise of total IgE by >50%. The A. fumigatus specific IgE increased in only five (38.5%) subjects during exacerbation. Thus, the total IgE is a useful test in monitoring treatment responses in ABPA while A. fumigatus specific IgE has limited utility.
- Subjects
IMMUNOGLOBULIN E; ASPERGILLUS fumigatus; PULMONARY aspergillosis; ASTHMA; CYSTIC fibrosis
- Publication
Mycoses, 2016, Vol 59, Issue 1, p1
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.12423