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- Title
Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method.
- Authors
de Aléssio, Patrícia Vidal; Kogawa, Ana Carolina; Salgado, Hérida Regina Nunes
- Abstract
Ceftriaxone sodium, an antimicrobial agent that plays an important role in clinical practice, is successfully used to treat infections caused by most Gram-positive and Gram-negative organisms. Since there are few rapid analytical methods for ceftriaxone analysis to use in the pharmaceutical routine, the aim of this research was to develop a new method able to quantify this cephalosporin. Therefore, a sensitive, rapid, simple UV spectrophotometric method for the determination and quantification of ceftriaxone sodium was proposed. The UV detector was set at 241 nm. Beer’s law obeyed the concentration range of 10–20 µg mL−1. Statistical comparison of the results with a well-established reported method showed excellent agreement and proved that there is no significant difference in the accuracy and precision. Intra- and interday variability for the method were less than 2% relative standard deviation. The proposed method was applied to the determination of the examined drugs in pharmaceutical formulations and the results demonstrated that the method is equally accurate, precise, and reproducible as the official methods.
- Subjects
ANTI-infective agents; CEFTRIAXONE; GRAM-positive bacterial infections; CEPHALOSPORINS; ULTRAVIOLET detectors; BACTERIAL disease treatment
- Publication
Journal of Analytical Methods in Chemistry, 2017, p1
- ISSN
2090-8865
- Publication type
Article
- DOI
10.1155/2017/7530242