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- Title
A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia: results of a consensus process by an international working group.
- Authors
Barosi, G.; Besses, C.; Birgegard, G.; Briere, J.; Cervantes, F.; Finazzi, G.; Gisslinger, H.; Griesshammer, M.; Gugliotta, L.; Harrison, C.; Hasselbalch, H.; Lengfelder, E.; Reilly, J. T.; Michiels, J. J.; Barbui, T.
- Abstract
A widely accepted definition of resistance or intolerance to hydroxyurea (HU) in patients with essential thrombocythemia (ET) is lacking. An international working group (WG) was convened to develop a consensus formulation of clinically significant criteria for defining resistance/intolerance to HU in ET. To this aim, an analytic hierarchy process (AHP), a multiple-attribute decision-making technique, was used. The steps consisted of selecting the candidate criteria for defining resistance/intolerance; identifying the motivations that could influence the preference of the WG for any individual criterion; comparing the candidate criteria in a pair-wise manner; and grading them according their ability to fulfill the motivations. Every step in the model was derived by questionnaires or group discussion. The WG proposed that the definition of resistance/intolerance should require the fulfillment of at least one of the following criteria: platelet count greater than 600 000/μl after 3 months of at least 2 g/day of HU (2.5 g/day in patients with a body weight over 80 kg); platelet count greater than 400 000/μl and WBC less than 2500/μl or Hb less than 10 g/dl at any dose of HU; presence of leg ulcers or other unacceptable muco-cutaneous manifestations at any dose of HU; HU-related fever.Leukemia (2007) 21, 277–280. doi:10.1038/sj.leu.2404473; published online 16 November 2006
- Subjects
THROMBOCYTOSIS; DRUG resistance; DNA synthesis; DRUG therapy; BLOOD platelet disorders; CLINICAL trials
- Publication
Leukemia (08876924), 2007, Vol 21, Issue 2, p277
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/sj.leu.2404473