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- Title
Evaluation of malignant potential based on single infection status with high-risk human papillomaviruses 16, 52, and 58 in the uterine cervix.
- Authors
Juhun Lee; Yujin Heo; Hyun-Jung Lee
- Abstract
Objective: High-risk human papillomavirus (HR-HPV) is known as the most important carcinogen in uterine cervical carcinoma. Previous studies have evaluated genotype-specific risk for carcinogenesis. However, the genotype-specific risk remains still unclear due to some limitations of those studies. This study aimed to evaluate the malignant potential of the three most prevalent HR-HPVs in Korea. Methods: Patients who underwent cervical conization were included. They had received HPV test within a year before the surgery and those exhibiting concurrent multiple infections with HR-HPVs were excluded. Of single infections with HR-HPV, the three most prevalent HR-HPVs were included to analyze. The carcinoma in situ (CIS) in the final diagnosis included some cervical intraepithelial neoplasia 3 (CIN3) cases, which had been diagnosed with CIS. To evaluate their malignant potential, CIS+, including CIS and invasive carcinoma, was categorized in each HR-HPV group. The ratios of pathologic diagnoses and odds ratios for malignant potential were evaluated between the three most prevalent HR-HPVs. Results: Totally 230 patients were found to have a single infection with HR-HPV16, HR-HPV52, or HR-HPV58. The HPV16 group did not exhibit a significantly more CIS, invasive carcinoma, and CIS+ than HPV52 or HPV58. In the logistic regression analyses, in the evaluation of the malignant potential (CIS+), no significant difference was observed between the three single HR-HPV infection groups. Conclusion: Gynecologists should pay attention to not only HPV16 but also HPV52 and HPV58 because these genotypes have similar malignant potential. These findings support the need for a nine-valent vaccine against HR-HPVs in Korea.
- Subjects
HUMAN papillomavirus; CERVIX uteri; CERVICAL intraepithelial neoplasia; LOGISTIC regression analysis; GENITAL warts; CARCINOMA in situ
- Publication
Journal of Gynecologic Oncology, 2024, Vol 35, p39
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2024.35.S2.P37