We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tailored therapy and long-term surveillance of malignant germ cell tumors in the female genital system: 10-year experience.
- Authors
Qianying Zhao; Jiaxin Yang; Dongyan Cao; Jiangna Han; Kaifeng Xu; Yongjian Liu; Keng Shen
- Abstract
Objective: To explore the appropriate treatment of malignant germ cell tumor (MGCT) in the female genital system, and to analyze the factors influencing both therapeutic response and survival outcome. Methods: A cohort of 230-Chinese women diagnosed with MGCT of the genital system was retrospectively reviewed and prospectively followed. The demographic and pathological features, extent of disease and surgery, treatment efficiency, recurrence and survival were analyzed. Results: MGCTs from different genital origins shared a similar therapeutic strategy and response, except that all eight vaginal cases were infantile yolk sac tumors. The patients' cure rate following the initial treatment, 5-year overall survival and disease-free survival (DFS) were 85.02%, 95.00%, and 86.00%, respectively. Although more extensive excision could enhance the remission rate; it did not improve the patients' survival. Instead, the level of the medical institution, extent of surgery and disease were independent prognostic factors for relapse (p<0.05). Approximately 20% of patients had recurrent or refractory disease, more than half of whom were in remission following secondary cytoreductive surgery with salvage chemotherapy. Conclusion: Fertility-sparing surgery with or without standardized PEB/PVB (cisplatin, etoposide/vincristine, and bleomycin) chemotherapy is applicable for female MGCTs of different origins. Comprehensive staging is not required; nor is excessive debulking suggested. Appropriate cytoreduction by surgery and antineoplastic medicine at an experienced medical institution can bring about an excellent prognosis for these patients.
- Subjects
GERM cell tumors; ENDODERMAL sinus tumors; GERMINOMA; FEMALE reproductive organs; GENITALIA
- Publication
Journal of Gynecologic Oncology, 2016, Vol 27, Issue 3, p1
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2016.27.e26