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- Title
Environmental and genetic regulation of Streptococcus pneumoniae galactose catabolic pathways.
- Authors
Kareem, Banaz O.; Gazioglu, Ozcan; Mueller Brown, Karina; Habtom, Medhanie; Glanville, David G.; Oggioni, Marco R.; Andrew, Peter W.; Ulijasz, Andrew T.; Hiller, N. Luisa; Yesilkaya, Hasan
- Abstract
Efficient utilization of nutrients is crucial for microbial survival and virulence. The same nutrient may be utilized by multiple catabolic pathways, indicating that the physical and chemical environments for induction as well as their functional roles may differ. Here, we study the tagatose and Leloir pathways for galactose catabolism of the human pathogen Streptococcus pneumoniae. We show that galactose utilization potentiates pneumococcal virulence, the induction of galactose catabolic pathways is influenced differentially by the concentration of galactose and temperature, and sialic acid downregulates galactose catabolism. Furthermore, the genetic regulation and in vivo induction of each pathway differ, and both galactose catabolic pathways can be turned off with a galactose analogue in a substrate-specific manner, indicating that galactose catabolic pathways can be potential drug targets. Bacterial catabolism of galactose can occur via the tagatose pathway and/or the Leloir pathway. Here, the authors show that galactose utilization potentiates virulence of the pathogen Streptococcus pneumoniae, and the two pathways are induced by different environmental and chemical factors.
- Subjects
GENETIC regulation; GALACTOSE; STREPTOCOCCUS pneumoniae; ENVIRONMENTAL regulations; MICROBIAL virulence; SIALIC acids
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-49619-w