We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neurocognitive function of patients with brain metastases following gamma knife surgery: interim monitoring report of JLGK0901.
- Authors
Y. Higuchi; T. Serizawa; T. Shuto; A. Akabane; Y. Sato; J. Kawagishi; K. Yamanaka; M. Yamamoto
- Abstract
Purpose: To determine how the gamma knife surgery (GKS) affects the neurocognitive function of patients with brain metastases who included in prospective multi-institute study for brain metastases (JLGK0901). Method: Until Dec 2010, 859 patients were eligible for JLGK0901. We monitored neurocognitive function using Mini-Mental State Examination (MMSE) before GKS and at 4 and 12 months after GKS. We evaluated MMSE change, effects of pre-treatment status to MMSE score. We also divided into following 2 groups regarding pre-treatment MMSE score: Group A, MMSE score ≥27; Group B, ≤27. Neurocognitive change was defined as 3-point change in the MMSE score. Results: We evaluated MMSE for 776 patients (90.3%) before GKS. The mean score of MMSE was 27.2 ± 3.1 (mean ± standard deviation). Age >65, total tumor volume >3 cm³ and KPS£ 80 were significantly related to lower MMSE score. We obtained MMSE score of 350 patients (45.1%) at 4 months after GKS and 111 patients (14.3%) at 12 months after GKS. The MMSE scores were 28.1 ± 2.5 and 27.7 ± 3.6 at 4 months and 12 months after GKS, respectively. MMSE score significantly was increased at 4 months after GKS, respectively. There was no significant difference in MMSE score between pre-and 12 months after GKS. In most of group A patients, MMSE scores were stable during follow-up. Half of group B patients experienced improvement of MMSE scores. In both groups, neurocognitive deterioration was detected in approximately 10% of the patients. Conclusion: Minimum risk of deteriorating neurocognitive function was confirmed at least up to 12 months after GKS. No major adverse effects due to GKS occurred in this cohort. Follow-up of the patients study will be completed in 2013. This result will be updated in final report of JLGK0901 Disclosure: No significant relationships.
- Subjects
BRAIN metastasis; RADIOSURGERY; CANCER patients; COGNITIVE ability; BRAIN disease treatment; THERAPEUTICS
- Publication
Journal of Radiosurgery & SBRT, 2013, Vol 2, p173
- ISSN
2156-4639
- Publication type
Article