We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Proactive Treatment of Adult Facial Seborrhoeic Dermatitis with 0.1% Tacrolimus Ointment: Randomized, Double-blind, Vehicle-controlled, Multi-centre Trial.
- Authors
Tae-Wook KIM; Je-Ho MUN; Seung-Wook JWA; Margaret SONG; Hoon-Soo KIM; Hyun-Chang KO; Moon-Bum KIM; Ki-Hoon SONG; Sook-Kyung LEE; Jong-Keun SEO; Deborha LEE; Byung-Soo KIM
- Abstract
The effectiveness of intermittent topical tacrolimus to prevent relapse in patients with stabilized facial seborrhoeic dermatitis has not been evaluated. The aim of this study was to determine whether proactive use of 0.1% tacrolimus ointment can keep adult facial seborrhoeic dermatitis in remission. A total of 75 patients who had stabilized facial seborrhoeic dermatitis after 2 weeks' (open-label induction) treatment with 0.1% tacrolimus were randomized in a double-blind fashion to treatment with 0.1% tacrolimus once a week, twice a week, or vehicle twice a week, for 10 weeks (maintenance). Significant improvement in erythema, scaling and pruritus compared with baseline was maintained during the maintenance phase in both tacrolimus groups, but not in the vehicle group. The mean recurrence rate according to global assessment was significantly higher in the tacrolimus once-weekly group than in the twice-weekly group. In conclusion, twice-weekly treatment with 0.1% tacrolimus ointment had superior effects in keeping facial seborrhoeic dermatitis in remission.
- Subjects
SEBORRHEIC dermatitis; TACROLIMUS; SKIN inflammation; IMMUNOSUPPRESSIVE agents; FACE diseases
- Publication
Acta Dermato-Venereologica, 2013, Vol 93, Issue 5, p557
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-1532